産品詳情

産品編号：AF-214-14

産品描述：

IL-4 is a pleiotropic cytokine that regulates diverse T and Bλ cell responses including cell proliferation, survival and g≥ene expression. Produced by mast cells, T cells and‍ bone marrow stromal cells, IL-4 regulates the differentiaσtion of naive CD4+ T cells into helper Th2 cells, c♦haracterized by their cytokine-secretion profile tha t includes secretion of IL-4, IL-5, IL-6, IL-10, and IL-13, whi‍ch favor a humoral immune response. Another dominant function of I↔L-4 is the regulation of immunoglobulin class switching to the IgG1 and IgE isotypes. Ex♦cessive IL-4 production by Th2 cells has been associated with ↑elevated IgE production and allergy. Recombinant Murine IL-4 is a 13.5 kDa glo&bular protein containing 121 amino acid residues.

Manufactured using all Animal-Free reagents.

Source:E.coli

Synonyms:BCGF, BCDF, B cell stimulating factor (BSF-1)

AA Sequence:MHIHGCDKNH LREIIGILNE VTGEGTPCTE MDVPNVLTAT KNTTESELVC RASKVLRIFY LKHGKTPCLK KNSSVLMELQ R$LFRAFRCLD SSISCTMNES KSTSLKDFLE SLKSIMQMDY S

Purity:≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity:The ED50 was determined by the dose-dependent stimulation of the proliferation of mur®ine HT-2 cells is ≤ 2.0 ng/ml, corresponding to a specific activity oαf ≥ 5 x 105 units/mg

Calculated Molecular Weight:13.5 kDa

Accession Number:P07750

Gene ID:16189

Size

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1mg